The Oligonucleotide Therapeutics Society Presents the 2021 Virtual Conference

OTS 2021 Virtual Conference

SAN DIEGO, Sept. 04, 2021 (GLOBE NEWSWIRE) — The Oligo Meeting is purposefully designed to bring people together to share incredible advancements in the field of oligonucleotide therapeutics. While still unable to come together in person, OTS leadership believes in the power of sharing science and the dedicated organizing committee has planned a professional, outstanding, and exciting event in which attendees will join leading scientists from around the world.

Last year’s virtual meeting was extraordinarily successful, and this year’s virtual conference has been carefully planned to be even more seamlessly engaging and productive. All the components of the in-person annual meeting will be included: sessions, short talks, posters, exhibitors, and networking, which will be accessed through one online platform. Recorded talks and posters can be viewed on-demand through December 31, 2021, for all registered delegates. A fun and interactive networking tool will be available throughout the entire four days of the meeting, 24 hours a day.

Session topics feature Nucleic Acid Chemistry, Rare Diseases, 20th Anniversary of Mammalian RNAi, Delivery, Genome and RNA Editing, Bob Letsinger, PhD – 100 Years of History, and the Awards Presentation. The final sessions include two Oligonucleotide Preclinical sessions and finish with the highly anticipated Clinical Studies session.

This year’s featured event speakers include an outstanding lineup of leading experts covering a broad range of oligonucleotide-based disciplines.

Stanley T. Crooke, MD, PhD, Founder and CEO of n-Lorem Foundation and founder, former CEO, and Chairman of the Board at Ionis led the scientific development of a new platform for drug discovery: antisense technology. He engineered the creation of one of the largest, more advanced development pipelines in the biotechnology industry.

John Maraganore, PhD, is the CEO and Director of Alnylam Pharmaceuticals, which has led the translation of RNA interference from Nobel Prize-winning discovery into an innovative, entirely new class of medicines.

Marie Wikström Lindholm, PhD, SVP and Head of Molecular Design at Silence Therapeutics built and leads a skilled team at Silence focusing on fine-tuning the design of their proprietary GalNAc-conjugated siRNA technology and exploring siRNA delivery outside the hepatocyte.

Craig Mello, PhD, is a joint winner of the 2006 Nobel Prize in Physiology or Medicine for the discovery of RNA interference. He has been involved in several RNAi-based biotechnology companies and recently co-founded Atalanta Therapeutics.

Kelvin K. Ogilvie, PhD, a leading expert on biotechnology, bioorganic chemistry, and genetic engineering, invented the drug Ganciclovir and developed a general method for the chemical synthesis of large RNA molecules, which is still the basis for RNA synthesis worldwide.

Laura Sepp-Lorenzino, PhD oversees all drug research across in vivo and engineered cell therapy areas as Chief Scientific Officer at Intellia Therapeutics, Inc., a company developing curative genome editing treatments to positively transform the lives of people with genetic diseases.

These are just a few of the many experts that attendees will hear from as they present interesting and cutting-edge topics. Last year’s virtual conference received rave reviews from participants and this year’s virtual meeting is expected to be even more spectacular.

Those wishing to attend can register here.

Media Contact:

Geri Beaty

Phone: (619)795-9458

Email: info@oligotherapeutics.org

Related Images

 
OTS 2021 Virtual Conference

This content was issued through the press release distribution service at Newswire.com.

Attachment

OKEx เร่งการนำ NFT ไปใช้ด้วย DeFi Hub, NFT Marketplace

OKEx ยังคงมุ่งมั่นต่อการพัฒนาอุตสาหกรรมคริปโตและการเงินแบบไร้ศูนย์กลางด้วยการเปิดตัว DeFi Hub

วิคตอเรีย, เซเชลส์, Sept. 04, 2021 (GLOBE NEWSWIRE) — OKEx (www.okex.com) จุดแลกเปลี่ยนสกุลเงินคริปโตเคอเรนซี่และอนุพันธ์ชั้นนำระดับโลก วันนี้ได้ประกาศเปิดตัว DeFi Hub ระบบนิเวศสินทรัพย์ดิจิทัลแบบไร้ศูนย์กลาง ปัจจุบันแพลตฟอร์มนี้มีผลิตภัณฑ์หลัก 2 รายการ ได้แก่: NFT Marketplace และ DeFi Dashboard

NFT Marketplace นั้นเป็นแพลตฟอร์ม NFT แบบ End-to-End ที่สร้างขึ้นเพื่อช่วยส่งเสริมผู้สร้างและสร้างแรงบันดาลใจให้นักสะสม ทุกคนสามารถซื้อ ขาย และแลกเปลี่ยน NFT ได้โดยตรงผ่านแพลตฟอร์มนี้ โดยไม่ต้องจ่ายค่าธรรมเนียมให้ OKEx สิ่งที่ทำให้ NFT Marketplace ความโดดเด่นกว่าก็คือ ทุกคนสามารถใช้แพลตฟอร์มนี้เพื่อสร้าง NFT ของตนเองได้ทุกประเภท โดยใช้บล็อกเชน OEC หรือ Ethereum

จะสามารถซื้อ NFT ที่สร้างขึ้นใหม่ได้บน NFT Marketplace และผู้สร้างจะได้รับความยืดหยุ่นในการตั้งค่าค่าลิขสิทธิ์ของตนเอง ซึ่งแสดงให้เห็นถึงความมุ่งมั่นของ OKEx ในการปกป้องผลประโยชน์ของผู้สร้าง โดยที่ผู้สร้างจะได้รับค่าสิทธิสำหรับทุกธุรกรรมหลังจากนั้นในตลาดรองของ NFT Marketplace นอกจากนี้ NFT Marketplace ยังช่วยให้ผู้ใช้สามารถนำเข้า NFT ที่ถูกสร้างขึ้นบนแพลตฟอร์มอื่นๆ ที่รองรับ

DeFi Hub ยังเสนอวิธีการดูและจัดการสินทรัพย์แบบไร้ศูนย์กลางทั่วเครือข่ายบล็อกเชนหลักและโปรโตคอล DeFi DeFi Dashboard จะแสดงทั้งมุมมองพอร์ตการลงทุนทั้งหมด ตลอดจนมุมมองแยกต่างหากสำหรับของดิจิทัลที่สะสมได้

“ตลาด NFT กำลังได้รับความนิยมเพิ่มขึ้นอย่างรวดเร็ว ทำให้เกิดความต้องการระบบที่ครอบคลุมสำหรับการจัดการ NFT” Lennix Lai ผู้อำนวยการ OKEx กล่าวในแถลงการณ์ เขาได้กล่าวต่อ:

“DeFi Hub ได้ช่วยเราในการสร้าง NFT Marketplace ที่จะเร่งการนำ NFT ไปใช้โดยทำให้ทุกคนสามารถสร้าง แลกเปลี่ยน และขาย NFT ได้ง่ายกว่าที่เคย เรายังรู้สึกตื่นเต้นที่จะเปิดตัว DeFi Dashboard เพื่อนำเสนอการปรับปรุงที่จำเป็นอย่างมากด้านการแสดงภาพพอร์ตลงทุนคริปโตเคอเรนซี่ต่อผู้ใช้

เกี่ยวกับ OKEx

OKEx ก่อตั้งขึ้นในปี 2017 เป็นหนึ่งในจุดแลกเปลี่ยนสกุลเงินคริปโตเคอเรนซี่และอนุพันธ์ชั้นนำของโลก OKEx ได้นำเทคโนโลยีบล็อกเชนมาใช้ในเชิงนวัตกรรม เพื่อเปลี่ยนโฉมระบบนิเวศทางการเงิน และนำเสนอผลิตภัณฑ์ โซลูชัน และเครื่องมือการซื้อขายที่หลากหลายและซับซ้อนที่สุดในตลาด ผลิตภัณฑ์และบริการคริปโตที่ครอบคลุม ความมุ่งมั่นอย่างแน่วแน่ต่อการสร้างนวัตกรรม และการดำเนินงานในท้องถิ่นเพื่อให้บริการผู้ใช้ได้ดียิ่งขึ้น ทำให้ OKEx มุ่งมั่นที่จะขจัดอุปสรรคทางการเงิน และตระหนักถึงโลกแห่งบริการทางการเงินสำหรับทุกคน

ติดต่อเรา 

Vivien Choi / Andrea Leung

media@okex.com

47.8 Per Cent Of Malaysia’s Population Fully Vaccinated

A total of 47.8 per cent of the country’s population or 15,606,818 individuals, have completed their COVID-19 vaccination as of Friday, according to the COVID-19 Vaccine Supply Access Guarantee Special Committee (JKJAV).

JKJAV through an infographic shared on its official Twitter informed that as of yesterday, 20,261,734 individuals or 62 per cent have received the first dose, bringing the total number of vaccine doses dispensed under the National COVID-19 Immunisation Programme (PICK) to 35,841,103 doses.

In addition, the infographic shared that as of yesterday 66.7 per cent of the adult population have completed both doses of the vaccine as compared to 65.9 per cent, on Thursday.

Meanwhile, on the daily vaccination, a total of 321,349 doses were administered yesterday, of which 177,518 as the second dose and the remaining 143,831 the first dose.

PICK was launched on Feb 24 to curb the spread of COVID-19 pandemic in the country.

Source: NAM News Network

COVID: New Cases Drop To 19,057 Saturday – Msian Health DG

A total of 19,057 new COVID-19 cases were reported today, down from 19,378 cases yesterday (Sept 3).

Health director-general Dr Noor Hisham Abdullah, in a posting on Facebook and Twitter, said this brought the cumulative number of COVID-19 infections in Malaysia to 1,824,439.

Selangor remains the state with the highest number of new COVID-19 infections with 3,775 cases, followed by Sarawak (2,723), Sabah (2,279), Johor (2,077), Penang (1,558), Perak (1,450), Kelantan (1,434) and Kedah (1,329).

Kuala Lumpur recorded 711 new cases, Terengganu (605), Pahang (410), Melaka (338), Negeri Sembilan (242), Perlis (99), Putrajaya (18) while Labuan reported nine cases.

Source: NAM News Network

Highly Indebted Chinese Companies Pose Challenge for Beijing

In the latest sign that corporate debt levels in China pose a threat to the broader economy, Chinese regulators on Friday were forced to halt trading in bonds issued by Evergrande, the country’s second-largest property developer. Concerns that the company will be unable to continue making payments on its obligations prompted a huge sell-off by investors, overwhelming exchanges.

The rush to unload bonds issued by the company — some were selling for as little as 26% of their face value — came after a report from Bloomberg that said two major trust companies that have made large loans to Evergrande had demanded immediate repayment.

The crisis at Evergrande comes just days after another major Chinese firm, China Huarong Asset Management, released a long-delayed earnings report showing it had lost $15.9 billion last year and that its debt-to-equity ratio at one point totaled an eye-popping 1,333%.

State-owned financial firms engineered a bailout of Huarong late last month to avoid a collapse that could have been catastrophic for the economy. However, there has been no indication of a similar soft landing for Evergrande, which has been selling off assets in a rush to raise the cash needed to satisfy lenders.

The companies’ response

Huarong told investors last Sunday that it believes it will be able to continue paying its creditors, and that in the “near future” it will begin selling off non-core business units to raise additional cash and replenish its capital. The company had already sold off more than half of its non-financial subsidiaries.

Evergrande, earlier this week, was forced to warn investors in an earnings statement that the group “has risks of defaults on borrowings and cases of litigation outside of its normal course of business,” adding, “Shareholders and potential investors are advised to exercise caution when dealing in the securities of the group.”

Nevertheless, a company statement said, “The group will do its utmost to continue its operations and endeavor to deliver properties to customers as scheduled.”

Debt defaults rising

The problem of unsustainable debt is not limited to huge firms like Evergrande and Huarong. In both 2019 and 2020, Chinese firms defaulted on more than $20 billion in debt, and analysts believe that 2021 is on pace to set a new record.

“Debt, whether public or private, does seem to be an Achilles heel for China, and accounting practices and reporting are murky,” said Doug Barry, a spokesperson for the U.S.-China Business Council.

“The state-owned enterprises are huge, with some of them hugely inefficient. It’s a problem that has caught the attention of government regulators, an important first step in fixing it,” Barry said. “The private sector is important to China’s future growth and care must be taken to avoid clamping down too hard on it.”

Beijing cracking down

In one sense, the spate of defaults can be seen as good news, insofar as it signals that the Chinese government has recognized that past practices were unsustainable. For years, large money-losing Chinese companies have been kept afloat by waves of new loans, often issued with the government’s blessing.

For the past several years, regulators in China have been trying to crack down on these so-called “zombie” companies, which divert assets from profitable enterprises, creating a drag on the economy.

Beijing’s increasing willingness to let firms default and go out of business, while painful in the short term, could be laying the groundwork for a stronger economy in the future. However, weak transparency requirements for onshore debt issuance make the real depth of the debt problem hard to discern.

‘China has a serious zombie problem’

“The Chinese economy has been suffering from excessive non-financial corporate debt for a long time,” said Tianlei Huang, a research fellow at the Peterson Institute for International Economics. “As a result, China has a serious zombie problem. Across the country, there are probably tens of thousands zombie firms that are persistently making losses but kept alive only by continuous bank credit and government subsidies.”

According to the Bank for International Settlements, at the end of 2020, the total debt issued to non-financial corporations in China equaled 161% of the country’s GDP. That was significantly higher than the average for G-20 countries (102%) and even the average for emerging market economies (119%).

“Excessive non-financial corporate debt may pose a threat to the stability of the broader financial system,” said Huang, who corresponded with VOA by email.

Bankers getting nervous

Over the years, Chinese banks, sometimes with the encouragement of government officials, have issued hundreds of billions of dollars in loans to Chinese firms. As defaults increase, banks’ ability to absorb loan losses will deteriorate.

There are signs that bankers are getting nervous. In July, China Guangfa Bank moved to freeze some of Evergrande’s assets out of fear that the company would be unable to satisfy a loan set to come due next March.

Evergrande’s struggle is particularly worrisome to banks because of what it says about the real estate development sector more broadly. Loans to real estate ventures make up a large share of the loan portfolios of Chinese banks, so if Evergrande is unable to service its debts, that will call into question the quality of the other real estate-based assets on bank balance sheets.

Difficult balancing act

Until recently, there had been an implicit assumption among many lenders and investors that large distressed companies in China were considered “too big to fail” and would be bailed out by the government.

By allowing a number of these firms to default on their obligations over the past few years, said Huang, “Beijing was attempting to signal to all credit market participants that ‘too big to fail’ no longer holds and that it intends to allow more ill-managed state firms to default on their bonds.”

The bailout of Huarong this summer shows that, at least in some cases, Beijing will still feel the need to step in.

“The approach the Chinese regulators are taking is to expose risks in bond defaults gradually and at the same time to avoid anything that may explode abruptly, threatening financial stability,” said Huang. “This means there will be fewer government bailouts going forward, but for companies viewed as systemically or strategically important, bailouts will probably continue.”

Source: Voice of America

Protests Erupt in Bangkok After PM Survives Confidence Vote

Pro-democracy demonstrations erupted in Bangkok after Premier Prayuth Chan-ocha’s parliamentary allies helped him survive a no-confidence vote called after rising public anger at his government and its handling of the latest coronavirus outbreak.

Thousands marched through Bangkok’s commercial center Saturday shortly after lawmakers voted 264 to 208 to knock down the motion brought by the opposition against Prayuth, a former army chief, who has clung to power since leading a 2014 coup.

Thailand has been trapped on a carousel of coups, mass protests and short-lived civilian governments for 15 years. As army chief, Prayuth toppled the elected government of Yingluck Shinawatra and has since transformed into a civilian leader, backstopped by a fully appointed senate, the military, business elite and all-important monarchy.

Protesters say he has presided over an increasingly authoritarian government, while inequality has soared during his seven-year tenure.

Anger is bubbling among the mainly young protesters who are back on the streets nightly in large numbers after 18 months of calls for political reform, including to the once untouchable monarchy.

On Saturday, demonstrators found their planned routes to embassies blocked by shipping containers topped with razor wire, while hundreds of riot police corralled them away from sensitive sites. As night fell, hardcore protesters hurled firecrackers toward police lines.

“Inside or outside parliament, they hold all the power,” Baifern Benjama, 19, told VOA.

“When they cling onto power like this all we can do is take to the streets.”

Three no confidence motions against Prayuth have been defeated since 2019 by a legislature dominated by allies of the military-establishment he represents.

Another young protester said desperation was building and warned that could tip the country toward violence, with Prayuth refusing to give any ground.

“Non-violence won’t work against this regime,” said Billie, 22, giving one name. “I can’t just stand and watch. I had to come out to protest and everyone else should, too.”

Prayuth’s government has come under intense pressure over its handling of the pandemic, which has killed 12,537 since April 1 in the deadliest outbreak so far.

Just 13 percent of the country has been fully inoculated against the coronavirus that causes COVID-19, raising questions about the sluggish rollout and a flip-flopping vaccine procurement strategy.

The government has defended its pandemic response, pointing to an uptick in the vaccination rate over recent weeks as a sign of its efforts in the face of a crisis without precedent.

Speaking after the failed bid to vote him out, the famously gruff Prayuth swatted away questions of his desire to carry on against mounting protests.

“My heart is like a fist, the fist of the prime minister,” Prayuth said from his car window, before punching his chest twice and driving off.

‘Going backwards’

Southeast Asia’s second biggest economy has taken its worst battering since 1997; household debt is soaring and tourists who accounted for 20%-25% of GDP pre-pandemic are not expected back in serious numbers for several months.

The months of anti-government protests have frayed the credibility of the conservative establishment, with a mix of anger and ridicule pouring across social media as the government struggles to get a grip on the pandemic and the ensuing economic pain it has heaped on Thais.

Experts say the momentum had been building toward an early general election before the scheduled 2024 poll. But Prayuth’s latest political escape act in parliament has potentially stalled that progress.

“But our politics is still so shaky and there’s still a chance for a dissolution of the parliament,” Pita Limjaroenrat, leader of the second biggest opposition party, Move Forward, said after the vote. “Political mathematics is one thing, but we will have to see if that plays out into the government’s legitimacy.”

Experts warn the ongoing political instability will further weaken an economy that was already one of Asia’s least equal before the pandemic wiped out millions of jobs.

But the prognosis if Prayuth clings to power for the long term is bleak, according to Khemthong Tonsakulrungruang, a legal scholar at Bangkok’s Chulalongkorn University.

“If Prayuth stays in power, we’re not just going nowhere, we’re going backwards,” he added.

Another major rally is expected Sunday, this time organized by the Red Shirt supporters of former prime minister Yingluck and her family dynasty, for a key Bangkok intersection.

Source: Voice of America